OncoOne Establishes Scientific Advisory Board to Support its Modular PreTarg-it® Platform for Radionuclide Therapies
OncoOne, a biotechnology company utilizing its expert knowledge in antibody engineering to support the further growth of targeted radiopharmaceutical therapies globally, announced their new Scientific Advisory Board (SAB) members whose collective expertise spans foundational research, translational medicine and scientific collaborations. The interdisciplinary guidance from the SAB will be instrumental in advancing and broadening the company’s PreTarg-it®, a modular platform for pretargeted radioimmunotherapy that separates tumor targeting from radionuclide delivery by using a sequential approach to enable more precise irradiation while limiting damage to surrounding healthy tissue.
OncoOne Announces Formation of Clinical Advisory Board to Support Development of ON104 for Chronic Inflammatory Diseases
OncoOne, a biotechnology company focused on discovering precision medicines for cancer and autoimmune diseases, announced today the formation of a clinical advisory board to provide strategic and clinical insights for the company’s lead program in immunology, ON104. ON104 is a monoclonal antibody targeting the oxidized isoform of the macrophage migration inhibitory factor (oxMIF) for the treatment of chronic inflammatory diseases.
OncoOne Presents Preclinical Data Update from oxMIF-targeting Pipeline at the 2023 AACR Annual Meeting
OncoOne, a biotechnology company focused on discovering precision medicines for cancer and autoimmune diseases, announced today two poster presentations highlighting new preclinical data from its oxMIF-targeting drug candidate pipeline at the upcoming American Association for Cancer Research (AACR) Annual Meeting 2023, held from April 14-19, in Orlando, Florida. The presentations will feature updated analyses for lead antibody candidate ON203 and first preclinical data from the company’s pre-targeted radioimmunotherapy program, ON-05, both of which demonstrated promising anti-tumor effects. ON203 and ON-05 target the oxidized macrophage migration inhibitory factor (oxMIF), a central regulator of innate immune cells in the tumor microenvironment (TME).
OncoOne Expands Scientific Advisory Board Adding Three World-Renowned MIF and Macrophage Experts to Support Upcoming Clinical Programs
OncoOne, a biotechnology company focused on discovering precision medicines for cancer and autoimmune diseases, today announced the appointment of three new members to its scientific advisory board to accelerate the clinical development of the company’s oxidized macrophage migration inhibitory factor (oxMIF)-targeting pipeline. oxMIF is the disease-related and druggable isoform of the macrophage migration inhibitory factor (MIF), a critical driver in innate and adaptive immunity in cancers and immunology. oxMIF is a promising new target which was discovered by the OncoOne founders.
OncoOne Presents Preclinical Proof of Concept Data for its Next-Generation oxMIF-targeted Monoclonal Antibody ON203 at the AACR Annual Meeting
OncoOne, a biotechnology company focused on discovering precision medicines for cancer and autoimmune diseases, announced today the presentation of preclinical proof-of-concept data on its lead candidate ON203, a therapeutic monoclonal antibody targeting oxMIF, and the radiodiagnostic 89Zr-ON102, at the American Association for Cancer Research (AACR) Annual Meeting 2022, held from April 8-13, in New Orleans, Louisiana. ON203 demonstrated tumor growth suppression in two cancer mouse models and superior tumor cell killing effects in vitro as compared to a first generation anti-oxMIF antibody which had reached clinical evaluation. Conference participants can access the data in both a poster format and an online oral presentation via the conference website. The poster #313 will be presented on Sunday, April 10 in the poster session “Antibodies and Immune Therapies”, from 1:30 – 5:00 pm CDT.
